AQUACEL^® Ag+ Extra™

AQUACEL^® Ag+ dressings comprise two powerful technologies working synergistically to manage the key local barriers to wound healing - exudate, infection and biofilm.

Ag+ Technology  is a unique ionic silver-containing, antibiofilm formulation that:^*1

• Disrupts and beaks down biofilm slime ro expose bateria^3-5

• Kills a broad spectrum of bacteria, including antibiotic resistant superbugs, with its reservoir of silver ^*4,5,6

• prevents biofilm formation^*4,5

Hydrofiber™ Technology helps create an ideal environment for healing – and for Ag+ Technology to work.

• Locks in excess exudate, bacteria and biofilm to help minimise cross infection and prevent maceration^*7-12

• Micro contours to the wound bed, maintaining optimal moisture balance and eliminating dead spaces where bacteria and biofilm can grow^*13-15

• responds to wound conditions by forming a cohesive gel, while helping to minimise pain associated with dressing changes^*16-18

AQUACEL^® Ag+ Extra™ dressing my be used for the management of:

• wounds as a barrier to bacterial penetration of the dressing as this may help reduce infection;
  
  
• wounds where there is an infection or an increased risk of infection (Extra™ only);

• diabetic foot ulcers, leg ulcers, (venous stasis ulcers, arterial ulcers and leg ulcers of mixed aetiology) and pressure ulcers/sores (partial & full thickness);

• surgical wounds;

• traumatic wounds;

• wounds that are prone to bleeding, such as wounds that have been mechanically or surgically debrided;

• oncology wounds with exudate, such as fungoides-cutaneous tumors, fungating carcinoma, cutaneous metastasis, Kaposi’s sarcoma, and angiosarcoma;

• wounds where bacteria are a suspected cause of (or a factor in) chronicity /non-progression.

In addition, AQUACEL^® Ag+ Ribbon dressing may be used for cavity and deep wounds including sinus, undermining and tracking wounds.

*As demonstrated in vitro

References

1. Composition comprising antimicrobial metal ions and a quaternary cationic surfactant. Scientific Background Report. WO 2012136968 A1, 2012, Data on file, ConvaTec Inc.

2 - Assessment of the in vitro Physical Properties of AQUACEL^® EXTRA™, AQUACEL^®Ag EXTRA™ and AQUACEL^® Ag+ EXTRA™ dressings. Scientific background report. WHRIA3817 TA297, 2013, Data on File, ConvaTec Inc.

3. Physical Disruption of Biofilm by AQUACEL^® Ag+ Wound Dressing. Scientific Background Report. WHRI3850 MA232, 2013, Data on file, ConvaTec Inc.

4. Antimicrobial activity and prevention of biofilm reformation by AQUACEL^® Ag+ EXTRA™ dressing. Scientific Background Report. WHRI3857 MA236, 2013, Data on file, ConvaTec Inc.

5. Antimicrobial activity against CA-MRSA and prevention of biofilm reformation by AQUACEL^® Ag+ EXTRA™ dressing. Scientific Background Report. WHRI3875 MA239, 2013, Data on file, ConvaTec Inc.

6. Bowler PG, Welsby S, Towers V, Booth V, Hogarth A, Rowlands V, Joseph A, et al, 2012. Multidrug-resistant organisms, wounds and topical antimicrobial protection. Int Wound J. 9: 387-396.  

7. Newman GR, Walker M, Hobot JA, Bowler PG, 2006. Visualisation of bacterial sequestration and bacterial activity within hydrating Hydrober™ wound dressings. Biomaterials; 27:1129-1139.

8. Walker M, Hobot JA, Newman GR, Bowler PG, 2003. Scanning electron microscopic examination of bacterial immobilization in a carboxymethyl cellulose (AQUACEL^®) and alginate dressing. Biomaterials; 24: 883-890.

9. Bowler PG, Jones SA, Davies BJ, Coyle E, 1999. Infection control properties of some wound dressings. J. Wound Care; 8: 499-502.

10. Walker M, Bowler PG, Cochrane CA, 2007. In vitro studies to show sequestration of matrix metalloproteinases by silver-containing wound care products. Ostomy/Wound Management. 2007; 53: 18-25.

11. Walker M and Parsons D, 2010. Hydrofiber Technology: its role in exudate management. Wounds UK; 6: 31-38.

12. Parsons D, Bowler PG, Myles V, Jones SA, 2005. Silver antimicrobial dressings in wound management: A comparison of antibacterial, physical and chemical characteristics. WOUNDS;17: 222-232.

13. Jones SA, Bowler PG, Walker M, 2005. Antimicrobial activity of silver-containing dressings is influenced by dressing conformability with a wound surface. WOUNDS; 17: 263-270.

14. Bowler P, Jones S, Towers V, Booth R, Parsons D, Walker M, 2010. Dressing conformability and silver-containing wound dressings. Wounds UK; 6: 14-20.

15. Walker M, Jones S, Parsons D, Booth R, Cochrane C, Bowler P, 2011. Evaluation of low-adherent antimicrobial dressings. Wounds UK; 7: 32-45.

16. Barnea Y, Armir A, Leshem D, Zaretski A, Weiss J, Shafir R, et al, 2004. Clinical comparative study of Aquacel and paraffin gauze dressing for split-skin donor site treatment. Ann Plast Surg; 53: 132-136.

17. Kogan L, Moldavsky M, Szvalb S, Govrin-Yehudain J, 2004. Comparative study of Aquacel and Silverol treatment in burns. Ann Burns Fire Disasters; 17: 201-207.

18. Brunner U, Eberlein T, 2000. Experiences with hydrofibres in the moist treatment of chronic wounds, in particular of diabetic foot. VASA; 29: 253-257.